transcript: Hey Vsauce, I'm Jake and in the incredible
game The Last of Us 60% of the global population, 4.25 billion people, more than the entirety
of Asia, have suddenly ceased to exist or are just no longer people. And scenarios like
this are nothing new, there have been hundreds and hundreds of movies and videogames that
cover similar events, but could a pandemic like what is depicted in The Last of Us...actually
happen? You only have to go back 95 years to 1918,
at the end of World War 1, to witness one of the most deadly and disastrous pandemics
in human history: The Spanish Flu. This variety of avian influenza killed an
estimated 50 to 100 million people, more than 3 times the amount who died in the actual
war, and with a worldwide population at the time of 1.85 billion, it wiped out 3-5% of
the entire planet; and that was only in one year. But the flu is a virus that actually exists,
and in the work of fiction The Last of Us we are dealing with an organism, a fungus...that
also...actually exists. Cordyceps are fungal parasites that infect
and take over insects. The most well known being ophiocordyceps unilateralis that infects
ants, turning them into zombies. A spore from the fungus enters the ant's body, taking over
its brain and controlling its movements. Not too long after, the ant finds a perfect spot
to die, the fruiting body of the fungus grows out of the ant's head, and a slew of spores
are released onto the unsuspecting ant population. It has been known to decimate entire colonies,
but luckily it only infects insects, and it's not like diseases can move from one species
to another...well.... An estimated 60% of all modern diseases came
from animals, specifically ones that we live in close contact with or have domesticated.
From cattle grew measles, tuberculosis and smallpox. From pigs and birds we have the
flu. From chimpanzees we have AIDS. All of these started out as infections that couldn't
be spread to humans, but after years and years of these microbes being around us, they adapted
to our biology. But we don't live in direct contact with ants,
and most people don't eat ants, so that's good...but other animals do, and then other
animals eat those animals, and at some point on this parasitic food chain lie humans. Considering how diseases mutated and progressed from domesticated animals to us, it isn't too far fetched to
think that a fungal infection like this, whose only purpose is to survive long enough to
spread, could adapt and evolve to lay claim to the top of that food chain. A great example of a microbe's ingenuity is
in Jared Diamond's amazing book 'Guns, Germs and Steel'. Jared talks about the bacterial
disease typhus and how it was transmitted to people by going from rat fleas to rats
to humans. But after a while, typhus figured out a much easier way to infect us: by cutting
out the unnecessary carriers and going directly from human body lice to humans. If a fungal parasite like the Cordycep could
infect humans like it does in The Last of Us, how long would it take? One of the biggest
differences between the Spanish Flu in 1918 and a modern day pandemic is how connected
we are. What would have taken two weeks to go from New York to Germany by boat, can be
done in 8hrs on a plane. Using the Global Epidemic and Mobility software and some parameters we know from the game, we can create a model and simulate what the transmission and spread
would look like. In about 60 days, the fungal parasite would
have infected the majority of the planet. And you know things are bad when not even
Madagascar is safe. But that isn't to say that the governments
of the world don't have plans in place. Most governments - and the United States in particular
- have strategies for biological threats, counterterrorism, and the one that applies
to this situation most, The National Strategy for Pandemic Influenza. In it their high estimate
for fatality domestically is 2 million, or less than 1% the population of the US. This
incredibly detailed 233 page document really drives home one main point, and that is "sustain
infrastructure and mitigate impact to the economy and the functioning of society". A virus or disease or parasite doesn't affect
power lines, cars, the internet...it affects the people who make those things work. When
60% of the entire population, over 4 billion people, just stop being - when the doctors,
the teachers, the mechanics, the mail men vanish, and what we know as society crumbles...all
that's left is...the last of us. And as always, thanks for watching.
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